Other compounds
SAMe
A substance the body makes from the amino acid methionine and uses in many processes. Studied for mood and joints.
46 products from US online stores, sorted by what 400 mg of SAMe costs – not by the price per pack.
$0.59Lowest cost
per 400 mg SAMe
- Prices checked Nov 1, 2026, US
- No paid placements
What does 400 mg mean?
- SAMe per serving in most of the products we checked
- 200–400 mgSAMe per serving in most of the products we checked
- 400 mg is about one serving: half of the 46 products we checked have up to 400 mg per serving, the other half more.
- There’s no official daily amount for SAMe.
We compare by 400 mg only so products line up – it’s not a recommendation. Not medical advice.
Where products miss quality points
How the 46 products score
- Very good 90+: 0
- Good 75+: 38
- Fair 60+: 0
- Low under 60: 8
8 products contain titanium dioxide – a food authority has banned, restricted or flagged it as a possible health risk. Their score is cut in half, so it’s always in the red range. Each product says why.
- have no seal from an independent testing program
- 100%have no seal from an independent testing program10 of 30 testing points for GMP, 15 for the 5 whose label says “third-party tested”
The full 30 testing points need an independent test. Every supplement sold in the US is made under the FDA’s GMP rules – the maker checks its own products, which gives 10 points. A seal from a testing program like NSF, USP or Informed Choice means a lab outside the company checks that what’s inside matches the label. Most brands don’t take part. That doesn’t make a product bad – without a seal, a clean product still gets up to 80.
We find seals on the label and in NSF’s public lists. USP and Informed Choice don’t let us search their lists automatically, so a seal that’s only in their lists can be missing. How the score works
Pack size
Compare packs of a similar size.
All sizes in one list can affect the results – big packs usually cost less per 400 mg. Pick a size above to compare packs that are alike.
46 products · cheapest per 400 mg SAMe first
- Rank 1
Vitacost
Synergy, SAM-e, 200 mg
Tablets
80Good qualityCountry not stated$0.59per 400 mg
Lowest
- Pack
- $17.5960 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 2
Nutricost
SAMe
Capsules
85Good qualityMade in USA$0.60per 400 mg
2% more
- Pack
- $35.95120 capsules60 servings
- SAMe per serving
- 400 mgin 2 capsules
- Pack lasts
- 60 daysif you take 2 capsules (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 3
NOW Foods
SAMe, 200 mg
Capsules
80Good qualityMade in Canada$0.61per 400 mg
4% more
- Pack
- $36.74120 capsules
- SAMe per serving
- 200 mgin 1 capsule
- Pack lasts
- 60 daysif you take 2 capsules (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 4
Phytoral
Sam-E
Capsules
80Good qualityCountry not stated$0.64per 400 mg
10% more
- Pack
- $28.9990 capsules45 servings
- SAMe per serving
- 400 mgin 2 capsules
- Pack lasts
- 45 daysif you take 2 capsules (400 mg) a day
phytoral.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 5
NutraLife
SAMe, 400 mg
Tablets
30Low qualityCountry not stated$0.65per 400 mg
11% more
- Pack
- $38.9660 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 6
NOW Foods
SAMe, 200 mg
Capsules
80Good qualityMade in Canada$0.65per 400 mg
11% more
- Pack
- $19.5860 capsules
- SAMe per serving
- 200 mgin 1 capsule
- Pack lasts
- 30 daysif you take 2 capsules (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 7
Nature's Craft
SAM-e
Capsules
80Good qualityMade in USA$0.67per 400 mg
14% more
- Pack
- $19.9960 capsules
- SAMe per serving
- 200 mgin 1 capsule
- Pack lasts
- 30 daysif you take 2 capsules (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 8
Nature's Craft
Sam-E
Capsules
80Good qualityCountry not stated$0.67per 400 mg
14% more
- Pack
- $19.9960 capsules
- SAMe per serving
- 200 mgin 1 capsule
- Pack lasts
- 30 daysif you take 2 capsules (400 mg) a day
shopnaturescraft.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 9
NutraLife
SAMe, 200 mg
Tablets
30Low qualityCountry not stated$0.68per 400 mg
16% more
- Pack
- $20.3460 tablets30 servings
- SAMe per serving
- 400 mgin 2 tablets
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 10
NutraLife
SAMe, 400 mg
Tablets
30Low qualityCountry not stated$0.68per 400 mg
16% more
- Pack
- $20.3430 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 30 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 11
Nature's Craft
SAM-e, 150 mg
Capsules
80Good qualityMade in USA$0.74per 400 mg
26% more
- Pack
- $24.9990 capsules
- SAMe per serving
- 150 mgin 1 capsule
- Pack lasts
- 30 daysif you take 3 capsules (450 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 12
Nature's Craft
Sam-E
Capsules
80Good qualityMade in USA$0.74per 400 mg
26% more
- Pack
- $24.9990 capsules
- SAMe per serving
- 150 mgin 1 capsule
- Pack lasts
- 30 daysif you take 3 capsules (450 mg) a day
shopnaturescraft.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 13
NOW Foods
SAMe, 400 mg
Tablets
80Good qualityMade in USA$0.76per 400 mg
30% more
- Pack
- $45.7060 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 14
California Gold Nutrition
SAMe, Disulfate Tosylate, 400 mg
Tablets
30Low qualityCountry not stated$0.80per 400 mg
36% more
- Pack
- $47.9460 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 15
Doctor's Best
SAM-e, 400 mg
Tablets
80Good qualityCountry not stated$0.82per 400 mg
39% more
- Pack
- $48.9960 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 16
Doctor's Best
SAM-e Double-Strength 400 mg
Tablets
80Good qualityCountry not stated$0.82per 400 mg
39% more
- Pack
- $48.9960 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
drbvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 17
Life Extension
SAMe S-Adenosyl-Methionine, 400 mg
Tablets
30Low qualityCountry not stated$0.88per 400 mg
49% more
- Pack
- $52.5060 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 18
Swanson Vitamins
SAMe
Tablets
80Good qualityCountry not stated$0.90per 400 mg
53% more
- Pack
- $26.9960 tablets30 servings
- SAMe per serving
- 400 mgin 2 tablets
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
swansonvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 19
NOW Foods
SAMe, 400 mg
Tablets
80Good qualityMade in USA$0.94per 400 mg
60% more
- Pack
- $28.1630 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 30 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 20
Swanson Vitamins
SAMe, 200 mg
Tablets
80Good qualityCountry not stated$0.94per 400 mg
60% more
- Pack
- $28.2260 tablets30 servings
- SAMe per serving
- 400 mgin 2 tablets
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 21
Life Extension
SAMe, S-Adenosyl-Methionine, 400 mg
Tablets
30Low qualityCountry not stated$0.95per 400 mg
62% more
- Pack
- $28.5030 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 30 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 22
Swanson Vitamins
SAMe, 400 mg
Tablets
80Good qualityCountry not stated$1.03per 400 mg
76% more
- Pack
- $30.9930 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 30 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 23
Swanson Vitamins
SAMe - Higher Strength
Tablets
80Good qualityCountry not stated$1.03per 400 mg
76% more
- Pack
- $30.9930 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 30 daysif you take 1 tablet (400 mg) a day
swansonvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 24
California Gold Nutrition
SAMe, Butanedisulfonate, 400 mg
Tablets
30Low qualityCountry not stated$1.12per 400 mg
91% more
- Pack
- $67.2460 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 25
Doctor's Best
SAM-e, 200 mg
Tablets
80Good qualityCountry not stated$1.13per 400 mg
93% more
- Pack
- $33.9960 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 26
Doctor's Best
SAM-e
Tablets
80Good qualityCountry not stated$1.13per 400 mg
93% more
- Pack
- $33.9960 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
drbvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 27
Jarrow Formulas
SAMe 400, 400 mg
Tablets
80Good qualityCountry not stated$1.16per 400 mg
98% more
- Pack
- $69.7560 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 28
Natural Factors
SAMe, 200 mg
Tablets
85Good qualityMade in USA$1.17per 400 mg
99% more
- Pack
- $34.9760 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 29
Natural Factors
SAMe, 200 mg
Tablets
85Good qualityMade in USA$1.26per 400 mg
115% more
- Pack
- $18.8730 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 15 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 30
Protocol for Life Balance
SAMe, 400 mg
Tablets
80Good qualityCountry not stated$1.31per 400 mg
124% more
- Pack
- $78.7560 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 31
Life Extension
SAMe S-Adenosyl-Methionine, 200 mg
Tablets
80Good qualityCountry not stated$1.35per 400 mg
130% more
- Pack
- $20.2530 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 15 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 32
Jarrow Formulas
SAMe 200, 200 mg
Tablets
80Good qualityCountry not stated$1.44per 400 mg
145% more
- Pack
- $43.1360 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 33
Jarrow Formulas
SAMe 400, 400 mg
Tablets
80Good qualityCountry not stated$1.50per 400 mg
156% more
- Pack
- $44.9630 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 30 daysif you take 1 tablet (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 34
Nature Made
SAM-e Complete, 200 mg
Tablets
80Good qualityCountry not stated$1.56per 400 mg
166% more
- Pack
- $46.7960 tablets30 servings
- SAMe per serving
- 400 mgin 2 tablets
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 35
Jarrow Formulas
SAMe - 200mg
Tablets
80Good qualityCountry not stated$1.57per 400 mg
167% more
- Pack
- $46.9960 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
jarrow.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 36
Jarrow Formulas
SAMe - 400mg
Tablets
80Good qualityCountry not stated$1.63per 400 mg
179% more
- Pack
- $48.9930 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 30 daysif you take 1 tablet (400 mg) a day
jarrow.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 37
Natural Factors
SAMe
Tablets
85Good qualityCountry not stated$1.67per 400 mg
184% more
- Pack
- $49.9560 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
naturalfactors.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 38
Source Naturals
SAMe
Tablets
80Good qualityCountry not stated$1.69per 400 mg
189% more
- Pack
- $50.7560 tablets30 servings
- SAMe per serving
- 400 mgin 2 tablets
- Pack lasts
- 30 daysif you take 2 tablets (400 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 39
Nature Made
SAM-e Complete
Tablets
80Good qualityCountry not stated$1.73per 400 mg
195% more
- Pack
- $62.1936 tablets
- SAMe per serving
- 400 mgin 1 tablet
- Pack lasts
- 36 daysif you take 1 tablet (400 mg) a day
naturemade.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 40
Natural Factors
SAMe
Tablets
85Good qualityCountry not stated$1.80per 400 mg
206% more
- Pack
- $26.9530 tablets
- SAMe per serving
- 200 mgin 1 tablet
- Pack lasts
- 15 daysif you take 2 tablets (400 mg) a day
naturalfactors.com (opens in a new tab)Checked Nov 1, 2026 · Label
Good to know
- Fact
- 380%more per 400 mg for the most expensive product than for the cheapest.
- Fact
- 2%more per 400 mg for the cheapest capsules than for the cheapest tablets.
How we checked: one-time price for each size in the store’s US online shop, before sales tax and shipping, without subscriptions or coupons. Prices change often, so check the store before you buy. More on how we check
The amount we compare by only makes products comparable – it is not a dosage recommendation. Not medical advice.
How we calculate
Cost per dose = price ÷ (servings × amount per serving) × comparison amount. Example: $119.99 for 74 servings with 24 g of protein each is 1,776 g of protein. $119.99 ÷ 1,776 g × 30 g = $2.03 per 30 g of protein.
Found a mistake or a product we should add? Email us