Fiber, probiotics & enzymes
Digestive enzymes
Helpers (enzymes) that split protein, fat and carbs, like the ones your body makes itself. Taken to make food easier to digest.
245 products from US online stores, sorted by what one serving costs – as the label defines it, not by the price per pack.
7¢Lowest cost
per serving
- Prices checked Nov 1, 2026, US
- No paid placements
Why per serving?
These products don’t share one ingredient amount we could compare by – many are mixes, others list units like FCC. So we compare the price of one serving as the label defines it. A serving can be 1 tablet or 4 capsules and hold more or less – check the label before you buy.
30–180servings per pack in most of the products we checked
Why are most quality scores low?
How the 245 products score
- Very good 90+: 14
- Good 75+: 93
- Fair 60+: 105
- Low under 60: 33
2 products contain artificial colors with an EU warning and titanium dioxide – a food authority has banned, restricted or flagged them as a possible health risk. Their score is cut in half, so it’s always in the red range. Each product says why.
- have no seal from an independent testing program
- 94%have no seal from an independent testing program10 of 30 testing points for GMP, 15 for the 11 whose label says “third-party tested”
- hide amounts in a “proprietary blend”
- 50%hide amounts in a “proprietary blend”5 of 20 transparency points – you only see the total
The full 30 testing points need an independent test. Every supplement sold in the US is made under the FDA’s GMP rules – the maker checks its own products, which gives 10 points. A seal from a testing program like NSF, USP or Informed Choice means a lab outside the company checks that what’s inside matches the label. Most brands don’t take part. That doesn’t make a product bad – without a seal, a clean product still gets up to 80.
We find seals on the label and in NSF’s public lists. USP and Informed Choice don’t let us search their lists automatically, so a seal that’s only in their lists can be missing. How the score works
Pack size
Compare packs of a similar size.
All sizes in one list can affect the results – big packs usually cost less per serving. Pick a size above to compare packs that are alike.
245 products · cheapest per serving first
- Rank 1
Natural Factors
Papaya Enzymes with Amylase & Bromelain
Enzyme blend · Tablets
80Good qualityMade in Canada7¢per serving
Lowest
- Pack
- $8.37120 tablets
- One serving
- 1 tablet
- Pack lasts
- 120 daysif you take 1 tablet a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 2
NOW Foods
Chewable Papaya Enzymes
Enzyme blend · Tablets
80Good qualityCountry not stated9.1¢per serving
31% more
- Pack
- $16.40360 tablets180 servings
- One serving
- 2 tablets
- Pack lasts
- 180 daysif you take 2 tablets a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 3
NOW Foods
Plant Enzymes
Plant enzymes · Capsules
65Fair qualityMade in USA9.2¢per serving
32% more
- Pack
- $22.04240 capsules
- One serving
- 1 capsule
- Pack lasts
- 240 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 4
Mason Natural
Chewable Papaya, Digestive Enzyme Complex, Peach
Enzyme blend · Tablets
30Low qualityMade in USA9.3¢per serving
33% more
- Pack
- $4.64100 tablets50 servings
- One serving
- 2 tablets
- Pack lasts
- 50 daysif you take 2 tablets a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 5
Natural Factors
Papaya Enzymes with Amylase & Bromelain
Enzyme blend · Tablets
80Good qualityMade in Canada9.6¢per serving
37% more
- Pack
- $5.7460 tablets
- One serving
- 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 6
NOW Foods
Pancreatin 2000
Animal enzymes (pancreatin) · Capsules
65Fair qualityMade in USA9.8¢per serving
40% more
- Pack
- $24.49250 capsules
- One serving
- 1 capsule
- Pack lasts
- 250 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 7
Natural Factors
Papaya Enzymes
Enzyme blend · Tablets
80Good qualityMade in Canada$0.10per serving
43% more
- Pack
- $11.95120 tablets
- One serving
- 1 tablet
- Pack lasts
- 120 daysif you take 1 tablet a day
naturalfactors.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 8
NOW Foods
Plant Enzymes
Plant enzymes · Capsules
65Fair qualityMade in USA$0.10per serving
46% more
- Pack
- $12.23120 capsules
- One serving
- 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 9
NOW Foods
Chewable Papaya Enzymes
Enzyme blend · Tablets
80Good qualityCountry not stated$0.11per serving
59% more
- Pack
- $9.95180 tablets90 servings
- One serving
- 2 tablets
- Pack lasts
- 90 daysif you take 2 tablets a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 10
Swanson Vitamins
Digestitol with Enzymes & BioPerine
Enzyme blend · Capsules
65Fair qualityCountry not stated$0.12per serving
72% more
- Pack
- $7.1960 capsules
- One serving
- 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule a day
swansonvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 11
NOW Foods
Pancreatin 2000
Animal enzymes (pancreatin) · Capsules
65Fair qualityMade in USA$0.12per serving
75% more
- Pack
- $12.23100 capsules
- One serving
- 1 capsule
- Pack lasts
- 100 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 12
Nutricost
Lactase Enzyme Complex, 3,000 ALU
Enzyme blend · Capsules
85Good qualityMade in USA$0.12per serving
79% more
- Pack
- $14.95120 capsules
- One serving
- 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 13
21st Century
Digestive Enzymes
Enzyme blend · Capsules
65Fair qualityCountry not stated$0.12per serving
79% more
- Pack
- $7.4960 capsules
- One serving
- 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule a day
21stcenturyvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 14
NOW Foods
Super Enzymes
Enzyme blend · Capsules
65Fair qualityMade in USA$0.13per serving
79% more
- Pack
- $22.53180 capsules
- One serving
- 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 15
Source Naturals
Daily Essential Enzymes, 500 mg
Enzyme blend · Capsules
65Fair qualityCountry not stated$0.13per serving
85% more
- Pack
- $46.55360 capsules
- One serving
- 1 capsule
- Pack lasts
- 360 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 16
Source Naturals
Daily Essential Enzymes, 500 mg
Enzyme blend · Capsules
80Good qualityCountry not stated$0.13per serving
88% more
- Pack
- $31.49240 capsules
- One serving
- 1 capsule
- Pack lasts
- 240 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 17
Mason Natural
Plant-Based Ultra Digestive Enzymes
Plant enzymes · Tablets
80Good qualityMade in USA$0.13per serving
89% more
- Pack
- $7.9360 tablets
- One serving
- 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 18
Natural Factors
Papaya Enzymes
Enzyme blend · Tablets
80Good qualityMade in Canada$0.13per serving
90% more
- Pack
- $7.9560 tablets
- One serving
- 1 tablet
- Pack lasts
- 60 daysif you take 1 tablet a day
naturalfactors.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 19
Source Naturals
Daily Essential Enzymes, 500 mg
Enzyme blend · Capsules
65Fair qualityCountry not stated$0.14per serving
97% more
- Pack
- $16.45120 capsules
- One serving
- 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 20
21st Century
Digestive Enzymes
Enzyme blend · Capsules
65Fair qualityCountry not stated$0.14per serving
97% more
- Pack
- $8.2460 capsules
- One serving
- 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 21
SFI Health
Digestive Enzymes
Enzyme blend · Capsules
65Fair qualityMade in USA$0.14per serving
99% more
- Pack
- $24.99180 capsules
- One serving
- 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 22
Nutricost
Lactase Enzyme Complex Capsules
Enzyme blend · Capsules
70Fair qualityCountry not stated$0.14per serving
103% more
- Pack
- $16.97120 capsules
- One serving
- 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule a day
nutricost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 23
Source Naturals
Daily Essential Enzymes
Plant enzymes · Capsules
65Fair qualityCountry not stated$0.15per serving
109% more
- Pack
- $34.99240 capsules
- One serving
- 1 capsule
- Pack lasts
- 240 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 24
Source Naturals
Daily Essential Enzymes, 500 mg
Enzyme blend · Capsules
80Good qualityCountry not stated$0.15per serving
109% more
- Pack
- $8.7560 capsules
- One serving
- 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 25
Swanson Vitamins
Digestive Enzymes
Enzyme blend · Tablets
80Good qualityCountry not stated$0.15per serving
109% more
- Pack
- $26.29180 tablets
- One serving
- 1 tablet
- Pack lasts
- 180 daysif you take 1 tablet a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 26
Swanson Vitamins
Digestive Enzymes
Enzyme blend · Tablets
80Good qualityCountry not stated$0.15per serving
109% more
- Pack
- $26.29180 tablets
- One serving
- 1 tablet
- Pack lasts
- 180 daysif you take 1 tablet a day
swansonvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 27
Enzymedica
Digest Basic
Not stated on the label · Capsules
56Low qualityMade in USA$0.15per serving
115% more
- Pack
- $26.99180 capsules
- One serving
- 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 28
Vitamatic
Pancreatin 10X Digestive Enzymes
Animal enzymes (pancreatin) · Capsules
80Good qualityMade in USA$0.15per serving
118% more
- Pack
- $18.99250 capsules125 servings
- One serving
- 2 capsules
- Pack lasts
- 125 daysif you take 2 capsules a day
vitamaticusa.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 29
NOW Foods
Super Enzymes
Enzyme blend · Tablets
65Fair qualityMade in USA$0.16per serving
124% more
- Pack
- $28.16180 tablets
- One serving
- 1 tablet
- Pack lasts
- 180 daysif you take 1 tablet a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 30
Vitamatic
Pancreatin
Animal enzymes (pancreatin) · Capsules
80Good qualityCountry not stated$0.16per serving
129% more
- Pack
- $19.95250 capsules125 servings
- One serving
- 2 capsules
- Pack lasts
- 125 daysif you take 2 capsules a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 31
Nature's Truth
Chewable Papaya Enzymes, Natural Tropical
Enzyme blend · Tablets
80Good qualityCountry not stated$0.16per serving
136% more
- Pack
- $6.59120 tablets40 servings
- One serving
- 3 tablets
- Pack lasts
- 40 daysif you take 3 tablets a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 32
NOW Foods
Super Enzymes
Enzyme blend · Capsules
65Fair qualityMade in USA$0.17per serving
139% more
- Pack
- $14.9990 capsules
- One serving
- 1 capsule
- Pack lasts
- 90 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 33
Nutricost
Digestive Enzymes, 620 mg
Enzyme blend · Capsules
85Good qualityMade in USA$0.17per serving
139% more
- Pack
- $19.99120 capsules
- One serving
- 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 34
Vitacost
Everyday, Digestive Enzymes
Enzyme blend · Capsules
80Good qualityCountry not stated$0.17per serving
145% more
- Pack
- $30.79180 capsules
- One serving
- 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 35
NOW Foods
Super Enzymes
Enzyme blend · Tablets
65Fair qualityMade in USA$0.18per serving
153% more
- Pack
- $15.9190 tablets
- One serving
- 1 tablet
- Pack lasts
- 90 daysif you take 1 tablet a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 36
NutraChamps
Digestive Enzymes with Prebiotics & Probiotics
With probiotics · Capsules
80Good qualityMade in USA$0.18per serving
154% more
- Pack
- $31.95180 capsules
- One serving
- 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 37
Country Life
Papaya Digestive Support, Pineapple Papaya
Not stated on the label · Tablets
41Low qualityMade in USA$0.18per serving
158% more
- Pack
- $22.49500 tablets125 servings
- One serving
- 4 tablets
- Pack lasts
- 125 daysif you take 4 tablets a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 38
Country Life
Papaya Digestive Support
Not stated on the label · Tablets
41Low qualityMade in USA$0.18per serving
158% more
- Pack
- $22.49500 tablets125 servings
- One serving
- 4 tablets
- Pack lasts
- 125 daysif you take 4 tablets a day
countrylifevitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 39
Swanson Vitamins
Digestive Enzymes
Enzyme blend · Tablets
65Fair qualityCountry not stated$0.18per serving
161% more
- Pack
- $16.3990 tablets
- One serving
- 1 tablet
- Pack lasts
- 90 daysif you take 1 tablet a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 40
Swanson Vitamins
Digestive Enzymes
Enzyme blend · Tablets
65Fair qualityCountry not stated$0.18per serving
161% more
- Pack
- $16.3990 tablets
- One serving
- 1 tablet
- Pack lasts
- 90 daysif you take 1 tablet a day
swansonvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
Good to know
- Fact
- 2,447%more per serving for the most expensive product than for the cheapest.
- Fact
- 154%more per serving for the cheapest with probiotics than for the cheapest enzyme blend.
How we checked: one-time price for each size in the store’s US online shop, before sales tax and shipping, without subscriptions or coupons. Prices change often, so check the store before you buy. More on how we check
The amount we compare by only makes products comparable – it is not a dosage recommendation. Not medical advice.
How we calculate
Cost per serving = price ÷ servings in the pack, with the serving as the label defines it.
Found a mistake or a product we should add? Email us