Collagen & connective tissue

Cissus quadrangularis

A climbing plant from Asia and Africa. Used in Indian medicine for bones and joints – studies in people are few.

8 products from US online stores, sorted by what 500 mg of cissus extract costs – not by the price per pack.

9.7¢Lowest cost
per 500 mg cissus extract

Prices checked Nov 1, 2026, US
No paid placements

What does 500 mg mean?

cissus extract per serving in the 8 products we checked: 1,000–1,200 mgcissus extract per serving in the 8 products we checked

500 mg is a fixed amount to compare by.
There’s no official daily amount for cissus extract.

We compare by 500 mg only so products line up – it’s not a recommendation. Not medical advice.

Where products miss quality points

How the 8 products score

Very good 90+: 0
Good 75+: 8
Fair 60+: 0
Low under 60: 0

have no seal from an independent testing program: 8 of 8have no seal from an independent testing program10 of 30 testing points for GMP, 15 for the 2 whose label says “third-party tested”

The full 30 testing points need an independent test. Every supplement sold in the US is made under the FDA’s GMP rules – the maker checks its own products, which gives 10 points. A seal from a testing program like NSF, USP or Informed Choice means a lab outside the company checks that what’s inside matches the label. Most brands don’t take part. That doesn’t make a product bad – without a seal, a clean product still gets up to 80.

We find seals on the label and in NSF’s public lists. USP and Informed Choice don’t let us search their lists automatically, so a seal that’s only in their lists can be missing. How the score works

Good to know

Fact: 126%more per 500 mg for the most expensive product than for the cheapest.

How we checked: one-time price for each size in the store’s US online shop, before sales tax and shipping, without subscriptions or coupons. Prices change often, so check the store before you buy. More on how we check

The amount we compare by only makes products comparable – it is not a dosage recommendation. Not medical advice.

How we calculate

Cost per dose = price ÷ (servings × amount per serving) × comparison amount. Example: $119.99 for 74 servings with 24 g of protein each is 1,776 g of protein. $119.99 ÷ 1,776 g × 30 g = $2.03 per 30 g of protein.

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Cissus quadrangularis

What does 500 mg mean?

Where products miss quality points

Pack size

Cissus

Cissus

Cissus Quadrangularis

Cissus Quadrangularis 40%

Cissus Quadrangularis

Cissus Quadrangularis Extract Supplement

Cissus Extract

Cissus (Cissus Quadrangularis)

Good to know