Fiber, probiotics & enzymes
Betaine HCl (with pepsin)
An acid in pill form, often with the enzyme pepsin. Taken to help the stomach digest protein – studies are few.
24 products from US online stores, sorted by what 650 mg of betaine HCl costs – not by the price per pack.
2¢Lowest cost
per 650 mg betaine HCl
- Prices checked Nov 1, 2026, US
- No paid placements
What does 650 mg mean?
- betaine HCl per serving in most of the products we checked
- 520–750 mgbetaine HCl per serving in most of the products we checked
- 650 mg is about one serving: half of the 24 products we checked have up to 650 mg per serving, the other half more.
- There’s no official daily amount for betaine HCl.
We compare by 650 mg only so products line up – it’s not a recommendation. Not medical advice.
Where products miss quality points
How the 24 products score
- Very good 90+: 0
- Good 75+: 24
- Fair 60+: 0
- Low under 60: 0
- have no seal from an independent testing program
- 100%have no seal from an independent testing program10 of 30 testing points for GMP, 15 for the 1 whose label says “third-party tested”
The full 30 testing points need an independent test. Every supplement sold in the US is made under the FDA’s GMP rules – the maker checks its own products, which gives 10 points. A seal from a testing program like NSF, USP or Informed Choice means a lab outside the company checks that what’s inside matches the label. Most brands don’t take part. That doesn’t make a product bad – without a seal, a clean product still gets up to 80.
We find seals on the label and in NSF’s public lists. USP and Informed Choice don’t let us search their lists automatically, so a seal that’s only in their lists can be missing. How the score works
Pack size
Compare packs of a similar size.
All sizes in one list can affect the results – big packs usually cost less per 650 mg. Pick a size above to compare packs that are alike.
24 products · cheapest per 650 mg betaine HCl first
- Rank 1
BulkSupplements
Betaine HCl Powder
Betaine HCl only · Powder
80Good qualityCountry not stated2¢per 650 mg
Lowest
- Pack
- $30.971,333 servings
- Betaine HCl per serving
- 750 mg
- Pack lasts
- 1,538 daysif you take 650 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 2
Nutricost
Betaine HCL Powder
Betaine HCl only · Powder
80Good qualityMade in USA2.6¢per 650 mg
29% more
- Pack
- $19.97500 g (1.1 lb)500 servings
- Betaine HCl per serving
- 1,000 mgin 1 g
- Pack lasts
- 769 daysif you take 650 mg a day
nutricost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 3
BulkSupplements
Betaine HCl Powder
Betaine HCl only · Powder
80Good qualityCountry not stated3.1¢per 650 mg
55% more
- Pack
- $23.97667 servings
- Betaine HCl per serving
- 750 mg
- Pack lasts
- 769 daysif you take 650 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 4
BulkSupplements
Betaine HCl Powder
Betaine HCl only · Powder
80Good qualityCountry not stated5.7¢per 650 mg
184% more
- Pack
- $21.97333 servings
- Betaine HCl per serving
- 750 mg
- Pack lasts
- 384 daysif you take 650 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 5
Best Naturals
Betaine HCl 648 mg
Betaine HCl only · Capsules
80Good qualityMade in USA6¢per 650 mg
200% more
- Pack
- $15.06250 capsules
- Betaine HCl per serving
- 648 mgin 1 capsule
- Pack lasts
- 250 daysif you take 1 capsule (648 mg) a day
shopbestnaturals.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 6
BulkSupplements
Betaine HCl Capsules
Betaine HCl only · Capsules
80Good qualityCountry not stated7.2¢per 650 mg
258% more
- Pack
- $19.97240 capsules
- Betaine HCl per serving
- 750 mgin 1 capsule
- Pack lasts
- 240 daysif you take 1 capsule (750 mg) a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 7
Nutricost
Betaine HCl + Pepsin
With pepsin · Capsules
85Good qualityMade in USA7.5¢per 650 mg
271% more
- Pack
- $17.95240 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 240 daysif you take 1 capsule (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 8
Doctor's Best
Betaine HCl Pepsin and Gentian Bitters
With pepsin · Capsules
80Good qualityCountry not stated9.7¢per 650 mg
383% more
- Pack
- $34.99360 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 360 daysif you take 1 capsule (650 mg) a day
drbvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 9
Doctor's Best
Betaine HCl, Pepsin and Gentian Bitters
With pepsin · Capsules
80Good qualityCountry not stated$0.10per 650 mg
397% more
- Pack
- $36.04360 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 360 daysif you take 1 capsule (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 10
BulkSupplements
Betaine HCl Powder
Betaine HCl only · Powder
80Good qualityCountry not stated$0.13per 650 mg
546% more
- Pack
- $19.97133 servings
- Betaine HCl per serving
- 750 mg
- Pack lasts
- 153 daysif you take 650 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 11
Doctor's Best
Betaine HCl Pepsin & Gentian Bitters
With pepsin · Capsules
80Good qualityCountry not stated$0.13per 650 mg
562% more
- Pack
- $15.99120 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 12
Doctor's Best
Betaine HCl Pepsin & Gentian Bitters
With pepsin · Capsules
80Good qualityCountry not stated$0.13per 650 mg
562% more
- Pack
- $15.99120 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule (650 mg) a day
drbvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 13
Solaray
High Potency Betaine HCl with Pepsin
With pepsin · Capsules
80Good qualityCountry not stated$0.13per 650 mg
563% more
- Pack
- $33.39250 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 250 daysif you take 1 capsule (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 14
Solaray
High Potency Betaine HCl with Pepsin
With pepsin · Capsules
80Good qualityCountry not stated$0.15per 650 mg
639% more
- Pack
- $14.89100 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 100 daysif you take 1 capsule (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 15
NaturesPlus
Betaine Hydrochloride, 600 mg
Betaine HCl only · Tablets
80Good qualityCountry not stated$0.17per 650 mg
736% more
- Pack
- $13.9890 tablets
- Betaine HCl per serving
- 600 mgin 1 tablet
- Pack lasts
- 45 daysif you take 2 tablets (1,200 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 16
Nature's Life
Betaine HCl, 648 mg
Betaine HCl only · Capsules
80Good qualityCountry not stated$0.20per 650 mg
870% more
- Pack
- $48.69250 capsules
- Betaine HCl per serving
- 648 mgin 1 capsule
- Pack lasts
- 250 daysif you take 1 capsule (648 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 17
NaturesPlus
Betaine Hydrochloride Tablets
Betaine HCl only · Tablets
80Good qualityCountry not stated$0.20per 650 mg
883% more
- Pack
- $16.4590 tablets
- Betaine HCl per serving
- 600 mgin 1 tablet
- Pack lasts
- 45 daysif you take 2 tablets (1,200 mg) a day
naturesplus.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 18
Source Naturals
Betaine HCl, 650 mg
Betaine HCl only · Tablets
80Good qualityCountry not stated$0.22per 650 mg
973% more
- Pack
- $38.89180 tablets
- Betaine HCl per serving
- 650 mgin 1 tablet
- Pack lasts
- 180 daysif you take 1 tablet (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 19
Swanson Vitamins
Betaine HCl Hydrochloric Acid with VegPeptase
Betaine HCl only · Capsules
80Good qualityCountry not stated$0.23per 650 mg
1,040% more
- Pack
- $28.69250 capsules
- Betaine HCl per serving
- 325 mgin 1 capsule
- Pack lasts
- 125 daysif you take 2 capsules (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 20
Swanson Vitamins
Betaine HCl Hydrochloric Acid with VegPeptase
Betaine HCl only · Capsules
80Good qualityCountry not stated$0.23per 650 mg
1,040% more
- Pack
- $28.69250 capsules
- Betaine HCl per serving
- 325 mgin 1 capsule
- Pack lasts
- 125 daysif you take 2 capsules (650 mg) a day
swansonvitamins.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 21
Metagenics
SpectraZyme Betaine HCl + Pepsin
With pepsin · Tablets
80Good qualityMade in USA$0.26per 650 mg
1,187% more
- Pack
- $69.95270 tablets135 servings
- Betaine HCl per serving
- 1,300 mgin 2 tablets
- Pack lasts
- 270 daysif you take 1 tablet (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 22
Pure Encapsulations
Betaine HCl Pepsin
With pepsin · Capsules
80Good qualityCountry not stated$0.27per 650 mg
1,228% more
- Pack
- $53.50250 capsules
- Betaine HCl per serving
- 520 mgin 1 capsule
- Pack lasts
- 125 daysif you take 2 capsules (1,040 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 23
Bluebonnet Nutrition
Betaine HCl & Pepsin
With pepsin · Capsules
80Good qualityMade in USA$0.27per 650 mg
1,240% more
- Pack
- $48.57180 capsules
- Betaine HCl per serving
- 650 mgin 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule (650 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 24
Metabolic Maintenance
Betaine Hydrochloride with Pepsin
With pepsin · Capsules
80Good qualityCountry not stated$0.50per 650 mg
2,399% more
- Pack
- $45.1590 capsules
- Betaine HCl per serving
- 648 mgin 1 capsule
- Pack lasts
- 90 daysif you take 1 capsule (648 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
Good to know
- Fact
- 2,399%more per 650 mg for the most expensive product than for the cheapest.
- Fact
- 271%more per 650 mg for the cheapest with pepsin than for the cheapest betaine hcl only.
How we checked: one-time price for each size in the store’s US online shop, before sales tax and shipping, without subscriptions or coupons. Prices change often, so check the store before you buy. More on how we check
The amount we compare by only makes products comparable – it is not a dosage recommendation. Not medical advice.
How we calculate
Cost per dose = price ÷ (servings × amount per serving) × comparison amount. Example: $119.99 for 74 servings with 24 g of protein each is 1,776 g of protein. $119.99 ÷ 1,776 g × 30 g = $2.03 per 30 g of protein.
Found a mistake or a product we should add? Email us