Herbs & botanicals
Berberine
A yellow, bitter substance from plants like barberry. Studied for blood sugar and blood fats – it can interact with many medicines.
128 products from US online stores, sorted by what 500 mg of berberine costs – not by the price per pack.
8.3¢Lowest cost
per 500 mg berberine
- Prices checked Nov 1, 2026, US
- No paid placements
What does 500 mg mean?
- berberine per serving in most of the products we checked
- 200–1,000 mgberberine per serving in most of the products we checked
- 500 mg is about one serving: half of the 128 products we checked have up to 500 mg per serving, the other half more.
- There’s no official daily amount for berberine.
We compare by 500 mg only so products line up – it’s not a recommendation. Not medical advice.
Where products miss quality points
How the 128 products score
- Very good 90+: 5
- Good 75+: 120
- Fair 60+: 3
- Low under 60: 0
- have no seal from an independent testing program
- 96%have no seal from an independent testing program10 of 30 testing points for GMP, 15 for the 20 whose label says “third-party tested”
The full 30 testing points need an independent test. Every supplement sold in the US is made under the FDA’s GMP rules – the maker checks its own products, which gives 10 points. A seal from a testing program like NSF, USP or Informed Choice means a lab outside the company checks that what’s inside matches the label. Most brands don’t take part. That doesn’t make a product bad – without a seal, a clean product still gets up to 80.
We find seals on the label and in NSF’s public lists. USP and Informed Choice don’t let us search their lists automatically, so a seal that’s only in their lists can be missing. How the score works
Pack size
Compare packs of a similar size.
All sizes in one list can affect the results – big packs usually cost less per 500 mg. Pick a size above to compare packs that are alike.
128 products · cheapest per 500 mg berberine first
- Rank 1
BulkSupplements
Berberine HCl Powder
Berberine HCl · Powder
75Good qualityCountry not stated8.3¢per 500 mg
Lowest
- Pack
- $166.972,000 servings
- Berberine per serving
- 500 mg
- Pack lasts
- 2,000 daysif you take 500 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 2
BulkSupplements
Berberine HCl Powder
Berberine HCl · Powder
75Good qualityCountry not stated9.4¢per 500 mg
13% more
- Pack
- $93.971,000 servings
- Berberine per serving
- 500 mg
- Pack lasts
- 1,000 daysif you take 500 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 3
BulkSupplements
Berberine HCl Powder
Berberine HCl · Powder
75Good qualityCountry not stated$0.11per 500 mg
34% more
- Pack
- $55.97500 servings
- Berberine per serving
- 500 mg
- Pack lasts
- 500 daysif you take 500 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 4
Best Naturals
Berberine, 500 mg
Berberine HCl · Capsules
75Good qualityMade in USA$0.17per 500 mg
100% more
- Pack
- $19.99120 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 5
BulkSupplements
Berberine HCl Powder
Berberine HCl · Powder
75Good qualityCountry not stated$0.17per 500 mg
103% more
- Pack
- $33.97200 servings
- Berberine per serving
- 500 mg
- Pack lasts
- 200 daysif you take 500 mg a day
bulksupplements.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 6
Amazing Nutrition
Berberine
Berberine HCl · Capsules
75Good qualityMade in USA$0.18per 500 mg
120% more
- Pack
- $21.99120 capsules60 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 7
Amazing Nutrition
Amazing Formulas Berberine
Berberine HCl · Capsules
75Good qualityMade in USA$0.18per 500 mg
120% more
- Pack
- $21.99120 capsules60 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
amazingnutrition.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 8
Amazing Nutrition
Herbal Secrets Berberine
Berberine HCl · Capsules
75Good qualityMade in USA$0.18per 500 mg
120% more
- Pack
- $21.99120 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
amazingnutrition.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 9
Amazing Nutrition
Berberine
Berberine HCl · Capsules
75Good qualityMade in USA$0.18per 500 mg
120% more
- Pack
- $11.0060 capsules30 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 10
Amazing Nutrition
Amazing Formulas Berberine
Berberine HCl · Capsules
75Good qualityMade in USA$0.20per 500 mg
139% more
- Pack
- $11.9960 capsules30 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
amazingnutrition.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 11
Advance Physician Formulas
Berberine 500 mg
Berberine HCl · Capsules
80Good qualityCountry not stated$0.22per 500 mg
166% more
- Pack
- $19.9590 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 90 daysif you take 1 capsule (500 mg) a day
physicianformulas.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 12
Advance Physician Formulas
Berberine, 500 mg
Berberine HCl · Capsules
75Good qualityCountry not stated$0.24per 500 mg
187% more
- Pack
- $21.5890 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 90 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 13
Force Factor
Berberine, 500 mg
Berberine HCl · Capsules
75Good qualityMade in USA$0.25per 500 mg
199% more
- Pack
- $14.9960 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 14
Vitamatic
Berberine, 500 mg
Berberine HCl · Capsules
73Fair qualityMade in USA$0.25per 500 mg
199% more
- Pack
- $14.9960 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 15
Vitamatic
Berberine 500mg Supplement
Berberine HCl · Capsules
75Good qualityMade in USA$0.25per 500 mg
199% more
- Pack
- $14.9960 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
vitamaticusa.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 16
Micro Ingredients
Berberine
Berberine HCl · Softgels
80Good qualityCountry not stated$0.25per 500 mg
199% more
- Pack
- $29.99240 softgels60 servings
- Berberine per serving
- 1,000 mgin 4 softgels
- Pack lasts
- 120 daysif you take 2 softgels (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 17
NOW Foods
Berberine HCl, 500 mg
Berberine HCl · Capsules
75Good qualityMade in USA$0.25per 500 mg
202% more
- Pack
- $22.6990 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 90 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 18
Nutricost
Berberine
Berberine HCl · Capsules
80Good qualityMade in USA$0.26per 500 mg
215% more
- Pack
- $18.9560 capsules30 servings
- Berberine per serving
- 1,200 mgin 2 capsules
- Pack lasts
- 60 daysif you take 1 capsule (600 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 19
EVLution Nutrition
Berberine
Berberine HCl · Capsules
75Good qualityCountry not stated$0.27per 500 mg
219% more
- Pack
- $15.9960 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
evlnutrition.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 20
Paradise Herbs
Berberine HCL
Berberine HCl · Capsules
75Good qualityMade in USA$0.27per 500 mg
219% more
- Pack
- $47.99180 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule (500 mg) a day
paradiseherbs.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 21
Micro Ingredients
Berberine 500mg with MCT Oil
Berberine HCl · Softgels
80Good qualityCountry not stated$0.27per 500 mg
229% more
- Pack
- $32.99240 softgels120 servings
- Berberine per serving
- 500 mgin 2 softgels
- Pack lasts
- 120 daysif you take 2 softgels (500 mg) a day
microingredients.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 22
Toniiq
Berberine 1500
Berberine HCl · Capsules
75Good qualityCountry not stated$0.28per 500 mg
233% more
- Pack
- $49.97180 capsules60 servings
- Berberine per serving
- 1,500 mgin 3 capsules
- Pack lasts
- 180 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 23
Toniiq
Berberine 1500
Berberine HCl · Capsules
75Good qualityCountry not stated$0.28per 500 mg
233% more
- Pack
- $49.97180 capsules60 servings
- Berberine per serving
- 1,500 mgin 3 capsules
- Pack lasts
- 180 daysif you take 1 capsule (500 mg) a day
toniiq.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 24
California Gold Nutrition
Berberine HCI, 500 mg
Berberine HCl · Capsules
75Good qualityCountry not stated$0.28per 500 mg
239% more
- Pack
- $33.94120 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 25
Nutricost
Berberine Capsules
Berberine HCl · Capsules
80Good qualityMade in USA$0.29per 500 mg
249% more
- Pack
- $20.9760 capsules30 servings
- Berberine per serving
- 1,200 mgin 2 capsules
- Pack lasts
- 60 daysif you take 1 capsule (600 mg) a day
nutricost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 26
Natural Factors
WellBetX, Berberine
Berberine HCl · Capsules
80Good qualityMade in Canada$0.29per 500 mg
249% more
- Pack
- $34.97120 capsules60 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 27
Sports Research
Berberine
Berberine HCl · Capsules
80Good qualityCountry not stated$0.29per 500 mg
249% more
- Pack
- $34.97120 capsules60 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 28
NOW Foods
Berberine Glucose Support
Berberine HCl · Softgels
75Good qualityMade in USA$0.31per 500 mg
266% more
- Pack
- $21.9990 softgels
- Berberine per serving
- 400 mgin 1 softgel
- Pack lasts
- 45 daysif you take 2 softgels (800 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 29
Source Naturals
Berberine, 500 mg
Berberine HCl · Capsules
75Good qualityCountry not stated$0.31per 500 mg
269% more
- Pack
- $36.98120 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 120 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 30
Vitacost
Berberine HCl, 500 mg
Berberine HCl · Capsules
75Good qualityCountry not stated$0.31per 500 mg
277% more
- Pack
- $15.7250 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 50 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 31
Source Naturals
Berberine, 500 mg
Berberine HCl · Capsules
75Good qualityCountry not stated$0.32per 500 mg
280% more
- Pack
- $19.0160 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 32
Sunergetic
Berberine
Berberine HCl · Capsules
75Good qualityCountry not stated$0.32per 500 mg
282% more
- Pack
- $22.9560 capsules30 servings
- Berberine per serving
- 1,200 mgin 2 capsules
- Pack lasts
- 60 daysif you take 1 capsule (600 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 33
Paradise Herbs
Berberine HCL
Berberine HCl · Capsules
75Good qualityMade in USA$0.32per 500 mg
289% more
- Pack
- $19.4960 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
paradiseherbs.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 34
Micro Ingredients
Berberine 1000mg with MCT Oil Softgels
Berberine HCl · Softgels
75Good qualityCountry not stated$0.33per 500 mg
298% more
- Pack
- $19.95120 softgels30 servings
- Berberine per serving
- 1,000 mgin 4 softgels
- Pack lasts
- 60 daysif you take 2 softgels (500 mg) a day
microingredients.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 35
Forest Leaf
Berberine HCI Complex
Berberine HCl · Capsules
60Fair qualityMade in USA$0.33per 500 mg
299% more
- Pack
- $29.9590 capsules45 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 90 daysif you take 1 capsule (500 mg) a day
forestleaf.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 36
Toniiq
Berberine
Berberine HCl · Capsules
75Good qualityCountry not stated$0.33per 500 mg
299% more
- Pack
- $29.9790 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 90 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 37
Toniiq
Berberine 97%
Berberine HCl · Capsules
75Good qualityCountry not stated$0.33per 500 mg
299% more
- Pack
- $29.9790 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 90 daysif you take 1 capsule (500 mg) a day
toniiq.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 38
Paradise Herbs
Berberine, 500 mg
Berberine HCl · Capsules
75Good qualityMade in USA$0.33per 500 mg
299% more
- Pack
- $59.99180 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 180 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 39
Source Naturals
Berberine, 500 mg
Berberine HCl · Capsules
75Good qualityCountry not stated$0.33per 500 mg
300% more
- Pack
- $10.0330 capsules
- Berberine per serving
- 500 mgin 1 capsule
- Pack lasts
- 30 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
- Rank 40
Natural Factors
WellBetX Berberine
Berberine HCl · Capsules
80Good qualityMade in Canada$0.34per 500 mg
305% more
- Pack
- $20.2760 capsules30 servings
- Berberine per serving
- 1,000 mgin 2 capsules
- Pack lasts
- 60 daysif you take 1 capsule (500 mg) a day
vitacost.com (opens in a new tab)Checked Nov 1, 2026 · Label
Good to know
- Fact
- 4,989%more per 500 mg for the most expensive product than for the cheapest.
- Fact
- 1,145%more per 500 mg for the cheapest dihydroberberine than for the cheapest berberine hcl.
How we checked: one-time price for each size in the store’s US online shop, before sales tax and shipping, without subscriptions or coupons. Prices change often, so check the store before you buy. More on how we check
The amount we compare by only makes products comparable – it is not a dosage recommendation. Not medical advice.
How we calculate
Cost per dose = price ÷ (servings × amount per serving) × comparison amount. Example: $119.99 for 74 servings with 24 g of protein each is 1,776 g of protein. $119.99 ÷ 1,776 g × 30 g = $2.03 per 30 g of protein.
Found a mistake or a product we should add? Email us